Cancer translational research combines results from the laboratories and also the clinics to discover new analytical procedures, treatment and prevention strategies against cancer. Apoptosis, in which a cell is developed to die, is one strategy by applying research like a new type of treatment method for cancer. The thought is inducing cancer cells to kill themselves. This new treatment approach is novel because available treatment plans have some of the disadvantages. But, this new finding also presents numerous problems.
Apoptosis is a common stress response
All cells are going to die. They may be designed to do this. It was shown to be a physiologic mechanism to keep homeostasis. Each time a toxic substance enters a cell, the choice would be to kill itself to retain the chemical and prevent it from causing further problems for other cells and tissues. Chemotherapeutic drugs which are used to treat cancer work as toxins to cancer cells. Thus there's a debate about how precisely feasible it is to get a cancer cell to kill itself via apoptosis or simply killing cancer cells via cytotoxic drugs.
Cell toxicity or cell death
Most chemotherapeutic drugs inhibit cancer cells by blocking DNA, MRNA or protein production, causing direct harm to DNA, blocking DNA replication enzymes or inducing chromosome separation. Cancer cells given these drugs may get damages towards the mitotic mechanism, cell membrane permeability or become senescent or old. There were reports that in cancer cells which may have intact apoptotic mechanisms, to follow their programmed cell death mechanism, in reaction for the toxins inside drugs. It's an argument in chemotherapy whether cells die due to the lethal effect of the toxin; or as the toxin has activated the suicidal mechanisms with the cells.
Helpful remarks on apoptosis
If chemotherapeutic drugs work thanks to either cell toxicity or cell death, does that then it signifies apoptosis research is so far useless? Not far. The new findings of apoptosis are not whatsoever futile, it was found that treatments involving chemotherapy adjunct with apoptosis inducers may be more effective. Acting alone, they'd struggle to get rid of the cancer progeny cells who have become proof against either therapy. A remedy which is intrinsically toxic and blocks a vital metabolic pathway can be more effective. Moreover, new facts about apoptosis may be used to assess the available treatments employed for cancer. A lot of issues have yet to be addressed in cancer translational research including searching for a safer plus much more effective treatment.
Apoptosis is a common stress response
All cells are going to die. They may be designed to do this. It was shown to be a physiologic mechanism to keep homeostasis. Each time a toxic substance enters a cell, the choice would be to kill itself to retain the chemical and prevent it from causing further problems for other cells and tissues. Chemotherapeutic drugs which are used to treat cancer work as toxins to cancer cells. Thus there's a debate about how precisely feasible it is to get a cancer cell to kill itself via apoptosis or simply killing cancer cells via cytotoxic drugs.
Cell toxicity or cell death
Most chemotherapeutic drugs inhibit cancer cells by blocking DNA, MRNA or protein production, causing direct harm to DNA, blocking DNA replication enzymes or inducing chromosome separation. Cancer cells given these drugs may get damages towards the mitotic mechanism, cell membrane permeability or become senescent or old. There were reports that in cancer cells which may have intact apoptotic mechanisms, to follow their programmed cell death mechanism, in reaction for the toxins inside drugs. It's an argument in chemotherapy whether cells die due to the lethal effect of the toxin; or as the toxin has activated the suicidal mechanisms with the cells.
Helpful remarks on apoptosis
If chemotherapeutic drugs work thanks to either cell toxicity or cell death, does that then it signifies apoptosis research is so far useless? Not far. The new findings of apoptosis are not whatsoever futile, it was found that treatments involving chemotherapy adjunct with apoptosis inducers may be more effective. Acting alone, they'd struggle to get rid of the cancer progeny cells who have become proof against either therapy. A remedy which is intrinsically toxic and blocks a vital metabolic pathway can be more effective. Moreover, new facts about apoptosis may be used to assess the available treatments employed for cancer. A lot of issues have yet to be addressed in cancer translational research including searching for a safer plus much more effective treatment.
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