Kamis, 30 Agustus 2012

Cancer Translational Research Resolving the Problem of Cancer

The cancer translational research seeks to find out the issues average cells carry on and split and form benign tumors or cancer growth. While the development may cause physiological destruction, this doesn't cause extensive damage if this spreads to the tissues. The issue arises when these cells spread along with other areas of the body and cause problems for internal organs. This leads to the organization of malignant or cancer cells. The symptoms rely on the nearby cells and tissues.
The difference between cancer and normal cells are modifications to the DNA and RNA. These mutations can happen unexpectedly or might be stimulated by a few environmental agents. Cancer is a huge worldwide problem for many years and contains been referred to as a public health risk globally. The cancer translational research efforts to provide solutions to questions regarding this disease. The approach utilizes laboratory findings and clinical researchers to obtain more findings and help out with resolving the problem of cancer. Early detection could mean the probability of discovering successful treatments. If researchers can easily identify the accurate location of the mutation along with exact mechanisms, this can generate remedies for that disease.
The problem is that financial support is not sufficient because translational principals are quite expensive. Support with this methodology is complicated given it demands funding support from the simple and easy clinical components generally from separate sources. Even if you'll find multiple reasons for funding for assorted components of translational research, they all have its very own restrictions.
Cancers have always been thought to be terminal previously before technology and knowledge were assembled to supply aspire to hopeless patients. As a result of cancer translational research, miracle cures have become remotely possible. Medical researchers are presently linked to focused research to find a way of fighting cancer if you use gene treatment. Some procedures necessitate opting for healthy cells and enhancing their capabilities to fight cancer while some attempt to destroy cancer cells preventing their growth.
Researchers have been in the midst of varied researches to improve the patient's disease fighting capability against cancer. Under this process, gene treatments are accustomed to accelerate your body's natural capacity to take care of cancer cells. Simultaneously, scientists are thinking about the potential for inserting genes into cancer cells to ensure they are more responsive to treatments like chemotherapy and radiation therapy. The materialization of gene therapy makes prospects brighter for cancer translational research.
High-frequency ultrasound and photoacoustics have showed new opportunities for Cancer Translational Research. For more details regarding Translational Research, please feel free checking out Visual Sonic Site.
Article Source: http://EzineArticles.com/?expert=Terry_R_Dancer

Article Source: http://EzineArticles.com/7155584

Rabu, 29 Agustus 2012

Does Calorie Restriction Extend Lifespan in Mammals?

Until about two years ago, the story went something like this: calorie restriction extends lifespan in yeast, worms, flies, and rodents. Lifespan extension by calorie restriction appears to be biologically universal, therefore it's probably only a matter of time until it's demonstrated in humans as well. More than 20 years ago, independent teams of researchers set out to demonstrate the phenomenon in macaque monkeys, a primate model closer to humans than any lifespan model previously tested.

Recent findings have caused me to seriously question this narrative. One of the first challenges was the finding that genetically wild mice (as opposed to inbred laboratory strains) do not live longer when their calorie intake is restricted, despite showing hormonal changes associated with longevity in other strains, although the restricted animals do develop less cancer (1). One of the biggest blows came in 2009, when researchers published the results of a study that analyzed the effect of calorie restriction on lifespan in 41 different strains of mice, both male and female (2). They found that calorie restriction extends lifespan in a subset of strains, but actually shortens lifespan in an even larger subset. Below is a graph of the effect of calorie restriction on lifespan in the 41 strains. Positive numbers indicate that calorie restriction extended life, while negative numbers indicate that it shortened life:

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Kamis, 23 Agustus 2012

Avast! Free Antivirus 7.0.1466

avast! Free Antivirus represents the best free antivirus protection currently available on the market. This edition is FREE OF CHARGE for non-commercial & home use. Its features include:
  • Anti-spyware built-in
  • Web Shield
  • Anti-rootkit built-in
  • Automatic updates
  • Strong self-protection
  • Virus Chest
  • Antivirus kernel
  • System integration
  • Simple User Interface
  • Integrated Virus Cleaner
  • Resident protection
  • Support for 64-bit Windows
  • P2P and IM Shields
  • Internationalization
  • Network Shield 
Title:Avast! Free Antivirus 7.0.1466
Filename:avast_free_antivirus_setup.exe
File size:89.32MB (93,654,616 bytes)
Requirements:Windows 2000 / XP / 2003 / Vista / Windows7 / XP64 / Vista64 / Windows7 64
Languages:Multiple languages
License:Non-Commercial Freeware
Date added:August 22, 2012
Author:Avast Software
www.avast.com
www.avast.com/free-antivirus-download
Homepage:www.avast.com/free-antivirus-download
MD5 Checksum:91510BECEC099F935D6D8CA3F48BC2D5

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Rabu, 22 Agustus 2012

AHS11 Talk Posted

After a one-year delay, my talk from the 2011 Ancestral Health Symposium is online with slides synched.  The talk is titled "Obesity: Old Solutions for a New Problem", and it's an overview of some of the research linking food reward to food intake and body fatness.  This is the talk that introduced a fundamentally new idea to the ancestral community: not only does the chemical composition of food matter, but also its sensory qualities-- in fact, the sensory qualities of food are among the primary determinants of food intake.  I didn't come up with the idea of course, I simply translated the research for a more general audience and put my own evolutionary spin on it.

The talk would be a bit different if I were to give it today, as my understanding of the subject has expanded, and my speaking skills have improved.  However, the central message remains as true today as it was a year ago.  You can find the talk here.

The slide synching was done by an extremely generous man named Ben Fury.  As you can see in the video, he did an excellent job.  Without Ben, this video would have remained in internet limbo forever.

Below, I've published a message from Ben explaining the interesting work that he does.  Please contact him if you think it's interesting.

A Message from Ben Fury

I was writing a book on health, fitness and diet in 2009 when my house burned down in the Station Fire, along with 165,000 acres of my beloved Angeles National Forest. Since then, I've had a series of people needing help come through my life, that have upgraded and morphed my talents...

Seniors with chronic pain, falls, brittle bones, and stiff shrunken muscles.
Diabetics with out of control blood sugars, going blind, and having limbs lopped off.
Neurologically challenged people with spastic limbs and foggy brains.
Fat, listless, unhappy people with no idea how they got that way, seeing no way out of the darkness.
Each of them needing help in different ways, but all with an underlying theme of what works to help heal our conditions:
  •     Remove flour, sugar, beans, and heavily processed oils from our diet. Eat real food.
  •     Get strong.
  •     Get flexible.
  •     Stop ceding health responsibility to outside forces, and take charge of our own wellness.
  •     Only use truly evidence based medicine. Don't just pop the latest pill or get the latest surgery all the other people are doing. Be wary of the disease mongers in both the conventional and alternative camps.
  •     Find our "happy thoughts." Use the simple restoratives of sleep, play, and reflection, to let go of pain, find inner peace, and let in joy and purposeful outer direction.
The methods to accomplish these goals are varied, and I have both non-profit and for-profit ventures to share them.
Their websites are currently in development.
The for-profit is BenFury.com
The non-profit is PainRelieversUSA.org , whose mission statement is:

To move beyond pain management...
and learn to live pain free.


Feel free to write to me  at:
 ben [at] benfury dot com

Kamis, 16 Agustus 2012

Ancestral Health Symposium 2012

I recently returned from AHS12 and a little side trip to visit family. The conference was hosted at Harvard University through the Harvard Food Law Society. Many thanks to all the organizers who made it happen. By and large, it went smoothly.

The science as expected ranged from outstanding to mediocre, but I was really encouraged by the presence and enthusiastic participation of a number of quality researchers and clinicians. The basic concept of ancestral health is something almost anyone can get behind: many of our modern health problems are due to a mismatch between the modern environment and what our bodies "expect". The basic idea is really just common sense, but of course the devil is in the details when you start trying to figure out what exactly our bodies expect, and how best to give it to them. I think our perspective as a community is moving in the right direction.

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Jumat, 10 Agustus 2012

Firefox 15.0 Beta 4

The Web is all about innovation, and Firefox sets the pace with dozens of new features to deliver a faster, more secure and customizable Web browsing experience for all.
User Experience. The enhancements to Firefox provide the best possible browsing experience on the Web. The new Firefox smart location bar, affectionately known as the "Awesome Bar," learns as people use it, adapting to user preferences and offering better fitting matches over time.
Performance. Firefox is built on top of the powerful new Gecko platform, resulting in a safer, easier to use and more personal product.
Security. Firefox raises the bar for security. The new malware and phishing protection helps protect from viruses, worms, trojans and spyware to keep people safe on the Web.
Customization. Everyone uses the Web differently, and Firefox lets users customize their browser with more than 5,000 add-ons.

Title:Firefox 15.0 Beta 4
Filename:Firefox Setup 15.0b4.exe
File size:17.50MB (18,349,064 bytes)
Requirements:Windows 2000 / XP / 2003 / Vista / Windows7 / XP64 / Vista64 / Windows7 64
Languages:en-US
License:Open Source
Date added:August 10, 2012
Author:Mozilla Organization
www.mozilla.org
www.mozilla.com/firefox/
Homepage:www.mozilla.com/firefox/
MD5 Checksum:49FC88FF42B42CF71F88993B5643440C
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Flash Player 11.4.400.252 Beta 2 (IE)

Adobe Flash Player is the high performance, lightweight, highly expressive client runtime that delivers powerful and consistent user experiences across major operating systems, browsers, mobile phones and devices.
Installed on over 750 million Internet-connected desktops and mobile devices, Flash Player enables organizations and individuals to build and deliver great digital experiences to their end users.
  • Immersive experiences with Flash video, content and applications with full-screen mode.
  • Low-bandwidth, high-quality video with advanced compression technology.
  • High-fidelity text using the advanced text rendering engine.
  • Real-time dynamic effects with filters for Blur, DropShadow, Glow, Bevel, Gradient Glow, Gradient Bevel, Displacement Map, Convolution, and Color Matrix.
  • Innovative media compositions with 8-bit video alpha channels.
  • Blend modes, radial gradient, and stroke enhancements.
  • Additional image formats: GIF, Progressive JPEG, and PNG.
This download is the standalone ActiveX installer for Internet Explorer.
Old versions of the Flash player can be downloaded from Adobe at http://www.adobe.com/go/tn_14266

Title:Flash Player 11.4.400.252 Beta 2 (IE)
Filename:flashplayer11-4_p2_install_win_ax_080712.exe
File size:9.14MB (9,579,720 bytes)
Requirements:Windows XP / 2003 / Vista / Windows7 / XP64 / Vista64 / Windows7 64
Languages:en-US
License:Freeware
Date added:August 9, 2012
Author:Adobe Systems Inc
www.adobe.com
www.adobe.com/products/flashplayer/
Homepage:www.adobe.com/products/flashplayer/
MD5 Checksum:96BE2064D0FC2719B70752793738C44B


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Comodo Dragon Internet Browser 21.0

Comodo Dragon is a Chromium technology-based Browser that offers you all of Chrome's features PLUS the unparalleled level of security and privacy you only get from Comodo. Including a greater level of privacy than Chromium technology offers.
Features:
  • Improved Privacy over Chromium
  • Easy SSL Certificate Identification
  • Fast Website Access
  • Greater Stability and Less Memory Bloat
  • Incognito Mode Stops Cookies, Improves Privacy
  • Very easy to switch from your Browser to the Dragon.

    Title:Comodo Dragon Internet Browser 21.0
    Filename:DragonSetup.exe
    File size:29.66MB (31,102,912 bytes)
    Requirements:Windows XP / Vista / Windows7
    Languages:Multiple languages
    License:Freeware
    Date added:August 10, 2012
    Author:Comodo
    www.comodogroup.com
    comodo.com/home/browsers-toolbars/browser.php
    Homepage:comodo.com/home/brow...olbars/browser.php
    MD5 Checksum:C43AE19056952EC5F7CB41FB67CB075A

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Avant Browser 2012 Build 180

Avant Browser is a standalone application designed to expand features provided by Internet Explorer. It adds a bunch of features and functionalities to IE and its user-friendly interface brings a new level of clarity and efficiency to your browsing experience, and frequent upgrades have steadily improved its reliability.
Avant Browser is freeware. That's right. 100% Free! No cost to you ever. No limitations. No Adware. No Spyware. You can donate if you want, but it's certainly not required.
Avant's features include:

  • Online Profile Storage
  • Autofills
  • Mouse Gestures
  • Flash Animation Filter
  • Built-in AD/Pop-up Blocker
  • Built-in RSS/ATOM Reader.
  • Additional Mouse Functions
  • Multi-Window Browsing
  • Real Full Screen Mode and Alternative Full Desktop mode
  • Built-in Search Engine
  • Full IE Compatibility
  • Control Your Privacy
  • Safe Recovery
  • Skins
  • Support for 41 languages

    Title:Avant Browser 2012 Build 180
    Filename:absetup.exe
    File size:3.67MB (3,844,152 bytes)
    Requirements:Windows (All Versions)
    Languages:Multiple languages
    License:Freeware
    Date added:August 9, 2012
    Author:Avant Force
    www.avantbrowser.com
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    MD5 Checksum:8B7F3048D01B41A87D80AD779B14368C

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Sabtu, 04 Agustus 2012

Lorcaserin: the Latest FDA-approved Obesity Drug

The FDA recently approved a new drug called lorcaserin (brand name Belviq) for the treatment of obesity. Lorcaserin causes an average of 13 lbs (5.8 kg) of weight loss over a year, compared to 5 lbs (2.2 kg) for placebo (1), which is less than the other recently approved drug Qsymia (formerly Qnexa; topiramate/phentermine).

Learning about obesity drugs is always a good opportunity to gain insight into the mechanisms that underlie the development and reversal of obesity. If you've been following this blog for a while, you already have a pretty good guess what organ this new drug acts on. Make your guess and read on!

Read more »

Kamis, 02 Agustus 2012

Two Great Quotes About Obesity (technical)

By Dr. Hans-Rudolf Berthoud, from a recent paper, "The Neurobiology of Food Intake in an Obesogenic Environment" (1). I came across it because it cites my review paper (2). My perspective on obesity is similar to his. From the abstract:
The modern lifestyle with its drastic changes in the way we eat and move puts pressure on the homoeostatic system responsible for the regulation of body weight, which has led to an increase in overweight and obesity. The power of food cues targeting susceptible emotions and cognitive brain functions, particularly of children and adolescents, is increasingly exploited by modern neuromarketing tools. Increased intake of energy-dense foods high in fat and sugar is not only adding more energy, but may also corrupt neural functions of brain systems involved in nutrient sensing as well as in hedonic, motivational and cognitive processing.
And a nice one from the conclusions:
Read more »

Rabu, 01 Agustus 2012

AntiVir Personal 12.0.0.1167

Avira AntiVir Personal - FREE Antivirus is a reliable free antivirus solution, that constantly and rapidly scans your computer for malicious programs such as viruses, Trojans, backdoor programs, hoaxes, worms, dialers etc. Monitors every action executed by the user or the operating system and reacts promptly when a malicious program is detected.
  • Detects and removes more than 150,000 viruses
  • Always among the winners of comparison test featured in computer journals
  • The resident Virus Guard serves to monitor file movements automatically, e.g. downloading of data from the internet
  • Scanning and repair of macro viruses
  • Protection against previously unknown macro viruses
  • Protection against trojans, worms, backdoors, jokes and other harmful programs
  • AntiVir protection against viruses, worms and Trojans
  • AntiDialer protection against expensive dialers
  • AntiRootkit protection against hidden rootkits
  • AntiPhishing protection against phishing
  • AntiSpyware protection against spyware and adware
  • NetbookSupport for laptops with low resolution
  • QuickRemoval eliminates viruses at the push of a button
  • Easy operation
  • Internet-Update Wizard for easy updating
  • Protection against previously unknown boot record viruses and master boot record viruses

    Title:AntiVir Personal 12.0.0.1167
    Filename:avira_free_antivirus_en.exe
    File size:85.92MB (90,098,552 bytes)
    Requirements:Windows 2000 / XP / Vista / Windows7 / XP64 / Vista64 / Windows7 64
    Languages:en-US
    License:Non-Commercial Freeware
    Date added:August 1, 2012
    Author:Avira GmbH
    www.avira.com
    www.free-av.com
    Homepage:www.free-av.com
    MD5 Checksum:E9B32E832EDDFA7B37FE1A847C40F928


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